The FGC (fast growing colony) line, a derivative of the LNCaP cell line shares all the main characteristics, including its androgen dependence, described for the original LNCaP cultures. A number of sublines originated from the FGC line which were characterized with respect to their response to steroid-depleted serum and to the synthetic androgen, R1881. After subcloning the FGC line a series of clones was isolated with distinct patterns of androgen-responsiveness. Among the sublines and clones studied, the FGC, FGC-JB and FGC clone-9 were androgen-dependent, whereas subline LNO, R and presumably also FGC clone-22 were androgen-independent. Distinct morphological differences were observed between the cells of the various sublines and between clone-9 and 22. The LNCaP cell line, its descending sublines and clonal derivatives provide a suitable in vitro model for studying different aspects of androgen-responsiveness of human prostate cancer.
LNCaP FGC：生長很快。是LNCaP的一種衍生細胞系，含有LNCaP的所有主要特征形狀，包含雄性激素依賴性。很多源于FGC的細胞株能對固醇類缺乏的血清有反應，和自我合成雄性激素，r1881. 克隆后，FGC細胞株表現出顯著的激素依賴行。在很多呀細胞株中和克隆中，FGC, FGC-JB and FGC clone-9是激素依賴性，但是亞細胞株 LNO, R and presumably also FGC 非激素依賴性。clone-22 和 clone-9形態(tài)學上有很大的差別。LNCaP細胞系及其他克隆為激素應答的前列腺癌癥的研究提供了合適和可靠體外模型。
LNCaP FGC：生長很快。是LNCaP的一種衍生細胞系，含有LNCaP的所有主要特征形狀，包含雄性激素依賴性。很多源于FGC的細胞株能對固醇類缺乏的血清有反應，和自我合成雄性激素，r1881. 克隆后，FGC細胞株表現出顯著的激素依賴行。在很多呀細胞株中和克隆中，FGC, FGC-JB and FGC clone-9是激素依賴性，但是亞細胞株 LNO, R and presumably also FGC 非激素依賴性。clone-22 和 clone-9形態(tài)學上有很大的差別。LNCaP細胞系及其他克隆為激素應答的前列腺癌癥的研究提供了合適和可靠體外模型。